The AAPS Journal - Vol. 12 Number 4, Dec 2010 Articles

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The AAPS Journal
Vol. 12 Number 4, Dec 2010

The AAPS Journal

Vol. 12 Number 4, Dec 2010

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Peptidomics of the Prolyl Peptidases
Author(s): Anna Mari Lone; Whitney M. Nolte; Arthur D. Tinoco; Alan Saghatelian
Delivery of siRNA Therapeutics: Barriers and Carriers
Author(s): Jie Wang; Ze Lu; M. Guillaume Wientjes; Jessie L.-S. Au
Investigation of the Ovarian and Prostate Cancer Peptidome for Candidate Early Detection Markers Using a Novel Nanoparticle Biomarker Capture Technology
Author(s): Claudia Fredolini; Francesco Meani; Alessandra Luchini; Weidong Zhou; Paul Russo; Mark Ross; Alexis Patanarut; Davide Tamburro; Guido Gambara; David Ornstein; Franco Odicino; Monica Ragnoli; Antonella Ravaggi; Francesco Novelli; Devis Collura; Leonardo D’Urso; Giovanni Muto; Claudio Belluco; Sergio Pecorelli; Lance Liotta; Emanuel F. Petricoin
Alginate–Chitosan–PLGA Composite Microspheres Enabling Single-Shot Hepatitis B Vaccination
Author(s): Xiaoling Zheng; Yongzhuo Huang; Caihong Zheng; Siyu Dong; Wenquan Liang
Breast Cancer Resistance Protein (BCRP) and Sulfotransferases Contribute Significantly to the Disposition of Genistein in Mouse Intestine
Author(s): Wei Zhu; Haiyan Xu; Stephen W. J. Wang; Ming Hu
Development of a Population Pharmacokinetic Model for Taranabant, a Cannibinoid-1 Receptor Inverse Agonist
Author(s): Xiujiang (Susie) Li; Jace Nielsen; Brenda Cirincione; Hankun Li; Carol Addy; John Wagner; Alan Hartford; Ngozi Erondu; Ira Gantz; Jerry Morgan; Julie Stone
A Novel MDR1 GT1292-3TG (Cys431Leu) Genetic Variation and Its Effect on P-glycoprotein Biologic Functions
Author(s): Matthew H. Crouthamel; Daniel Wu; Ziping Yang; Rodney J. Y. Ho
A Novel Ultrasensitive Hybridization-Based ELISA Method for 2-Methoxyphosphorothiolate MicroRNAs and Its In vitro and In vivo Application
Author(s): Kenneth K. Chan; Zhongfa Liu; Zhiliang Xie; Ming Chiu; Hongyan Wang; Ping Chen; Sarah Dunkerson; Michael Chiu; Shujun Liu; Georgia Triantafillou; Ramiro Garzon; Carlo M. Croce; John C. Byrd; Natarajan Muthusamy; Guido Marcucci
Controlled Crystallization of the Lipophilic Drug Fenofibrate During Freeze-Drying: Elucidation of the Mechanism by In-Line Raman Spectroscopy
Author(s): Hans Waard; Thomas Beer; Wouter L. J. Hinrichs; Chris Vervaet; Jean-Paul Remon; Henderik W. Frijlink
Ligand-Binding Mass Spectrometry to Study Biotransformation of Fusion Protein Drugs and Guide Immunoassay Development: Strategic Approach and Application to Peptibodies Targeting the Thrombopoietin Receptor
Author(s): Michael P. Hall; Colin Gegg; Kenneth Walker; Christopher Spahr; Robert Ortiz; Vimal Patel; Steven Yu; Liana Zhang; Hsieng Lu; Binodh DeSilva; Jean W. Lee
Bladder Tissue Pharmacokinetics of Intravesical Mitomycin C and Suramin in Dogs
Author(s): Leijun Hu; M. Guillaume Wientjes; Jing Li; Jessie L.-S. Au
Application of Quantitative Pharmacology in Development of Therapeutic Monoclonal Antibodies
Author(s): Mohammad Tabrizi; Cherryl Funelas; Hamza Suria

In Themed Issue: Pharmacokinetic/Pharmadynamic Modeling and Simulation in Drug Discovery and Translational Research
Investigation of the Performance of the Disintegration Test for Dietary Supplements
Author(s): May Almukainzi; Mahnor Salehi; Nadia Araci Bou-Chacra; Raimar Löbenberg
Similar Intracellular Peptide Profile of TAP1/β2 Microglobulin Double-Knockout Mice and C57BL/6 Wild-Type Mice as Revealed by Peptidomic Analysis
Author(s): Leandro M. Castro; Denise A. Berti; Lilian C. Russo; Verônica Coelho; Fábio C. Gozzo; Vitor Oliveira; Emer S. Ferro
Optimization of the Antitumor Activity of Sequence-specific Pyrrolobenzodiazepine Derivatives Based on their Affinity for ABC Transporters
Author(s): Maciej Kaliszczak; Dyeison Antonow; Katan I. Patel; Philip Howard; Duncan I. Jodrell; David E. Thurston; Sylvie M. Guichard
NonClinical Dose Formulation Analysis Method Validation and Sample Analysis
Author(s): Monica Lee Whitmire; Peter Bryan; Teresa R. Henry; John Holbrook; Paul Lehmann; Thomas Mollitor; Susan Ohorodnik; David Reed; Holly D. Wietgrefe
Neuropeptidomic Components Generated by Proteomic Functions in Secretory Vesicles for Cell–Cell Communication
Author(s): Vivian Hook; Steven Bark; Nitin Gupta; Mark Lortie; Weiya D. Lu; Nuno Bandeira; Lydiane Funkelstein; Jill Wegrzyn; Daniel T. O’Connor; Pavel Pevzner
Pharmacokinetics of Anti-hepcidin Monoclonal Antibody Ab 12B9m and Hepcidin in Cynomolgus Monkeys
Author(s): Jim J. Xiao; Wojciech Krzyzanski; Yow-Ming Wang; Hongyan Li; Mark J. Rose; Mark Ma; Yuling Wu; Beth Hinkle; Juan Jose Perez-Ruixo
Hemoglobin-derived Peptides as Novel Type of Bioactive Signaling Molecules
Author(s): Ivone Gomes; Camila S. Dale; Kimbie Casten; Miriam A. Geigner; Fabio C. Gozzo; Emer S. Ferro; Andrea S. Heimann; Lakshmi A. Devi
Application of Method Suitability for Drug Permeability Classification
Author(s): Donna A. Volpe

In Themed Issue: Pharmacokinetics, Biopharmaceutics and Bioequivalence: History and Perspectives
Fishing for the Hidden Peptidome in Health and Disease (Drug Abuse)
Author(s): Lloyd D. Fricker; Jonathan V. Sweedler
Modeling Disease Progression in Acute Stroke Using Clinical Assessment Scales
Author(s): Kristin E. Karlsson; Justin J. Wilkins; Fredrik Jonsson; Per-Henrik Zingmark; Mats O. Karlsson; E. Niclas Jonsson
Intracellular Gene Transfer in Rats by Tail Vein Injection of Plasmid DNA
Author(s): Tian Zhou; Kenya Kamimura; Guisheng Zhang; Dexi Liu
Pulmonary Immunization of Guinea Pigs with Diphtheria CRM-197 Antigen as Nanoparticle Aggregate Dry Powders Enhance Local and Systemic Immune Responses
Author(s): Pavan Muttil; Brian Pulliam; Lucila Garcia-Contreras; John Kevin Fallon; Chenchen Wang; Anthony James Hickey; David A. Edwards
Characterization of Particles in Protein Solutions: Reaching the Limits of Current Technologies
Author(s): Barthélemy Demeule; Steven Messick; Steven J. Shire; Jun Liu

In Themed Issue: Methods for Detecting and Characterizing Sub-visible Particulates
Multidimensional Atomic Force Microscopy: A Versatile Novel Technology for Nanopharmacology Research
Author(s): Ratnesh Lal; Srinivasan Ramachandran; Morton F. Arnsdorf
Pharmacodynamics-Mediated Drug Disposition (PDMDD) and Precursor Pool Lifespan Model for Single Dose of Romiplostim in Healthy Subjects
Author(s): Yow-Ming C. Wang; Wojciech Krzyzanski; Sameer Doshi; Jim J. Xiao; Juan Jose Pérez-Ruixo; Andrew T. Chow
Are Cutaneous Microdialysis Cytokine Findings Supported by End Point Biopsy Immunohistochemistry Findings?
Author(s): Florence Sjögren; Chris D. Anderson
Prediction of Exposure–Response Relationships to Support First-in-Human Study Design
Author(s): John P. Gibbs

In Themed Issue: Pharmacokinetic/Pharmadynamic Modeling and Simulation in Drug Discovery and Translational Research
Paracellular Tightness and Claudin-5 Expression is Increased in the BCEC/Astrocyte Blood–Brain Barrier Model by Increasing Media Buffer Capacity During Growth
Author(s): Hans Christian Helms; Helle Sønderby Waagepetersen; Carsten Uhd Nielsen; Birger Brodin

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