The AAPS Journal - Vol. 14 Number 2, Jun 2012 Articles

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Vol. 14 Number 2, Jun 2012

The AAPS Journal

Vol. 14 Number 2, Jun 2012

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A mechanism-Based Approach for Absorption Modeling: The Gastro-Intestinal Transit Time (GITT) Model
Author(s): Emilie Hénin; Martin Bergstrand; Joseph F. Standing; Mats O. Karlsson
Benet L Z and Galeazzi R L: Noncompartmental Determination of the Steady-State Volume of Distribution, J Pharm Sci 68, 1071–1074, 1979—the Backstory
Author(s): Leslie Z. Benet

In Themed Issue: Landmark Publications in the Pharmaceutical Sciences: The Backstory
Population Analyses of Efficacy and Safety of ABT-594 in Subjects with Diabetic Peripheral Neuropathic Pain
Author(s): Sandeep Dutta; Balakrishna S. Hosmane; Walid M. Awni
Rapid Sample Size Calculations for a Defined Likelihood Ratio Test-Based Power in Mixed-Effects Models
Author(s): Camille Vong; Martin Bergstrand; Joakim Nyberg; Mats O. Karlsson
Cutaneous Microdialysis: Cytokine Evidence for Altered Innate Reactivity in the Skin of Psoriasis Patients?
Author(s): Florence Sjögren; Karin Davidsson; Michael Sjöström; Chris D. Anderson
An Investigation into the Utility of a Multi-compartmental, Dynamic, System of the Upper Gastrointestinal Tract to Support Formulation Development and Establish Bioequivalence of Poorly Soluble Drugs
Author(s): Paul A. Dickinson; Ragheb Abu Rmaileh; Lee Ashworth; Richard A. Barker; Wendy M. Burke; Claire M. Patterson; Nick Stainforth; Mohammed Yasin
Conformational Analysis of Therapeutic Proteins by Hydroxyl Radical Protein Footprinting
Author(s): Caroline Watson; Joshua S. Sharp

In Themed Issue: Liquid Chromatography Mass Spectrometry for Therapeutic Macromolecules
Pharmacokinetic Evaluation of Intranasally Administered Vinyl Polymer-Coated Lorazepam Microparticles in Rabbits
Author(s): Yanjun Zhao; Marc B. Brown; Rajeshree H. Khengar; Matthew J. Traynor; Pedro Barata; Stuart A. Jones
Design and Characterization of Novel Peptide-Coated Lipid Nanoparticles for Targeting Anti-HIV Drug to CD4 Expressing Cells
Author(s): Aaron N. Endsley; Rodney J. Y. Ho
Issues and Challenges of Subvisible and Submicron Particulate Analysis in Protein Solutions
Author(s): Thomas M. Scherer; Stephenie Leung; Laura Owyang; Steven J. Shire

In Themed Issue: Methods for Detecting and Characterizing Sub-visible Particulates
The Solubility–Permeability Interplay and Its Implications in Formulation Design and Development for Poorly Soluble Drugs
Author(s): Arik Dahan; Jonathan M. Miller

In Themed Issue: Develop Enabling Technologies for Delivering Poorly Water Soluble Drugs: Current Status and Future Perspectives
Pharmacokinetics, Lymph Node Uptake, and Mechanistic PK Model of Near-Infrared Dye-Labeled Bevacizumab After IV and SC Administration in Mice
Author(s): Fang Wu; Mitalee Tamhane; Marilyn E. Morris
Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation
Author(s): Peng Zou; Yanke Yu; Nan Zheng; Yongsheng Yang; Hayley J. Paholak; Lawrence X. Yu; Duxin Sun
Challenges in Development of Nanoparticle-Based Therapeutics
Author(s): Neil Desai

In Themed Issue: Nanotechnology in Drug Development
Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy
Author(s): Narendra Chirmule; Vibha Jawa; Bernd Meibohm

In Themed Issue: Impact of Immunogenicity on PK/PD of Protein Therapeutics
Challenges in Development of Targeted Liposomal Therapeutics
Author(s): Rupa R. Sawant; Vladimir P. Torchilin

In Themed Issue: Nanotechnology in Drug Development
Ligand Binding Assays in the 21st Century Laboratory: Recommendations for Characterization and Supply of Critical Reagents
Author(s): Denise M. O’Hara; Valerie Theobald; Adrienne Clements Egan; Joel Usansky; Murli Krishna; Julie TerWee; Mauricio Maia; Frank P. Spriggs; John Kenney; Afshin Safavi; Jeannine Keefe
Role of Metabolism in the Effects of Genistein and Its Phase II Conjugates on the Growth of Human Breast Cell Lines
Author(s): Bo Yuan; Linglan Wang; Yi Jin; Huijuan Zhen; Pingwei Xu; Youjun Xu; Chibing Li; Haiyan Xu
Acarbose Bioequivalence: Exploration of New Pharmacodynamic Parameters
Author(s): Min Zhang; Jin Yang; Lei Tao; Lingjun Li; Pengcheng Ma; John Paul Fawcett
A Physiologically Based Pharmacokinetic Model of Mitoxantrone in Mice and Scale-up to Humans: a Semi-Mechanistic Model Incorporating DNA and Protein Binding
Author(s): Guohua An; Marilyn E. Morris
Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Rat Prefrontal Cortical Dopamine Response to Dual Acting Norepinephrine Reuptake Inhibitor and 5-HT1A Partial Agonist
Author(s): Cheryl Shuang-wu Li; Liming Zhang; Taraneh Haske; Amy Dounay; David Gray; Nancy Barta; Joanne Brodfuehrer; Christopher Lepsy; Brian Campbell

In Themed Issue: Pharmacokinetic/Pharmadynamic Modeling and Simulation in Drug Discovery and Translational Research

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