Vapor-induced transformations of docetaxel anhydrous (form DA) under ambient conditions have been studied using methanol, ethanol, and water as the solvent media. The online vapor-induced transformations were monitored by powder X-ray diffractometry. New solid forms (solvates/hydrates/anhydrous) of docetaxel anhydrous were obtained in stoichiometric ratios which were characterized completely using powder X-ray diffraction, differential scanning calorimeter, thermogravimetric analysis, and spectroscopic (13C solid-state nuclear magnetic spectroscopy, solution 1H NMR, and Fourier transform infrared) techniques. The new forms namely methanol solvate (DM), ethanol solvate (DE), monohydrate (DMH), trihydrate (DTH), and anhydrous (DAN-I and DAN-II) were identified through structural analysis.
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