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Author: Michael J. Treuheit, Andrew A. Kosky, David N. Brems
Keywords: aggregation,protein,agitation,shelf-life,polysorbate,stability
Summary: Concentration and Aggregation
prone to undesirable aggregation whereas partial unfolded
aggregation originates (9)
Pharmaceutical Research; Vol. 19 Number 4, Apr 2002;Published Date:03/31/2002; DOI: 10.1023/A:1015108115452
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Author: Sumie Yoshioka, Shinsuke Tajima, Yukio Aso, Shigeo Kojima
Keywords: inactivation,aggregation,β-galactosidase,molecular mobility,glass transition
Summary: Protein aggregation
ferent aggregation time constant (6) obtained by fitting the aggregation data to Eq.
Pharmaceutical Research; Vol. 20 Number 10, Oct 2003;Published Date:09/30/2003; DOI: 10.1023/A:1026151721212
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Author: Paolo Arosio, Simonetta Rima, Massimo Morbidelli
Keywords: aggregation,IgG subclass,kinetics,monoclonal antibody,oligomers
Summary: Methods The aggregation kinetics is analyzed by a combination of light scattering, size exclusion ch common features in aggregation behavior and the different observed aggregation mechanisms have been of the aggregation mechanism and of analogies among different proteins under different operating co
Pharmaceutical Research; Vol. 30 Number 3, Mar 2013;Published Date:02/28/2013; DOI: 10.1007/s11095-012-0885-3
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Author: Harminder Bajaj, Vikas K. Sharma, Advait Badkar, David Zeng, Sandeep Nema, Devendra S. Kalonia
Keywords: antibody formulation,monoclonal antibody,protein aggregation,protein stability,second viral coefficient
Summary: Both proteins readily aggregated at pH 4.0 (no aggregation observed at pH 7.4); the extent of
lead to long-term aggregation, it is unlikely that B22 will correlate with long-term aggregation. governed by the kinetics of aggregation of the aggregation-
Pharmaceutical Research; Vol. 23 Number 6, Jun 2006;Published Date:05/31/2006; DOI: 10.1007/s11095-006-0018-y
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Author: Vikas K. Sharma, Alexander M. Klibanov
Keywords: aggregation,DNA,lyophilization,moisture,relative humidity,solid state
Summary: To investigate the moisture-induced aggregation (i.e., a loss of solubility in water) of DNA in a
aggregation of DNA were examined. The extent of this aggregation was compared with that of a
Pharmaceutical Research; Vol. 24 Number 1, Jan 2007;Published Date:12/31/2006; DOI: 10.1007/s11095-006-9138-7
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Author: Nishant Kumar Jain, Ipsita Roy
Keywords: moisture-induced aggregation,protein stability,solid-dose formulation,tetanus toxoid,vaccine stability
Summary: induced aggregation, the amounts of water absorbed by the
The mechanism of degradation/aggregation of solid- KEY WORDS moisture-induced aggregation
Pharmaceutical Research; Vol. 28 Number 3, Mar 2011;Published Date:02/28/2011; DOI: 10.1007/s11095-010-0316-2
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Author: Eva Y. Chi, Sampathkumar Krishnan, Theodore W. Randolph, John F. Carpenter
Keywords: formulation,pharmaceuticals,denaturation,second virial coefficient,conformational stability
Summary: Irreversible protein aggregation is problematic in the biotechnology industry, where aggregation is
Nonnative aggregation
Nonnative protein aggregation (hereafter referred to
Pharmaceutical Research; Vol. 20 Number 9, Sep 2003;Published Date:08/31/2003; DOI: 10.1023/A:1025771421906
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Author: Wei Wang, Christopher J. Roberts
Keywords: Arrhenius,non-linear,prediction techniques,protein aggregation,shelf life
Summary: of protein aggregation remain a major focus in pharmaceutical companies and academic institutions. complexity of the aggregation process and temperature-dependent conformational stability, temperatu of protein aggregation, explores possible causes, and considers inherent hurdles for accurately ext
; DOI: 10.1208/s12248-013-9485-3
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