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Author: Sandra Klein
Keywords: BA,biorelevant media,dissolution,fasted state,fed state,food effects
Summary: The Use of Biorelevant Dissolution Media to Forecast the In Vivo Performance
and composition of biorelevant dissolution media that can be used for the
BA; biorelevant media; dissolution; fasted state; fed state; food effects.
The AAPS Journal; Vol. 12 Number 3, Sep 2010;Published Date:08/31/2010; DOI: 10.1208/s12248-010-9203-3
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Summary: Biorelevant dissolution/release testing is useful for the evaluation of formulation and food effects and utility of biorelevant dissolution studies to assess product performance attributes. ability of current biorelevant dissolution methods to predict in vivo performance to generate succe
Pharmaceutical Research; Vol. 30 Number 2, Feb 2013;Published Date:01/31/2013; DOI: 10.1007/s11095-012-0954-7
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Author: Marie Guhmann, Markus Thommes, Frédéric Gerber, Norbert Pöllinger, Sandra Klein, Jörg Breitkreutz, Werner Weitschies
Keywords: biorelevant test setups,diclofenac,mouth exposure,multiple absorption peaks,orodispersible tablets
Summary: Purpose Design of biorelevant test setups mimicking the physiological conditions experienced by dru Methods The biorelevant models simulated successively saliva (SSF , pH6.2�6.75�7.4, 5 mL, 3 min), ga evaluated for dissolution and further characterized by HPLC, optical morphogranulometry, DSC and PX
Pharmaceutical Research; Vol. 30 Number 6, Jun 2013;Published Date:05/31/2013; DOI: 10.1007/s11095-013-0974-y
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Author: Eleftheria Nicolaides, Moira Symillides, Jennifer B. Dressman, Christos Reppas
Keywords: prediction,oral absorption,lipophilic drugs,troglitazone,atovaquone,sanfetrinem cilexetil,GV150013X
Summary: Biorelevant Dissolution Testing to
Analysis of the In Vitro Dissolution Data
the in vitro dissolution test conditions have been previously
Pharmaceutical Research; Vol. 18 Number 3, Mar 2001;Published Date:02/28/2001; DOI: 10.1023/A:1011071401306
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Author: N. Parrott, V. Lukacova, G. Fraczkiewicz, M. B. Bolger
Keywords: food effect,formulation,GastroPlus,pharmacokinetics,physiologically based absorption model
Summary: drug properties, biorelevant solubility and dissolution, dissolution are described. food on the GI tract physiology, drug dissolution, and drug
The AAPS Journal; Vol. 11 Number 1, Mar 2009;Published Date:02/28/2009; DOI: 10.1208/s12248-008-9079-7
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Author: Ekarat Jantratid, Niels Janssen, Christos Reppas, Jennifer B. Dressman
Keywords: biorelevant media,dissolution media,duodenum,postprandial,preprandial,stomach
Summary: The aim of this study was to update the compositions of biorelevant media to represent the
as under usual dissolution test conditions. biorelevant media; dissolution media; duodenum; postprandial; preprandial; stomach.
Pharmaceutical Research; Vol. 25 Number 7, Jul 2008;Published Date:06/30/2008; DOI: 10.1007/s11095-008-9569-4
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Author: Maria Vardakou, Annalisa Mercuri, Susan A. Barker, Duncan Q. M. Craig, Richard M. Faulks, Martin S. J. Wickham
Keywords: gastric shear forces,biorelevant in vitro models,dynamic gastric model,in vitro–in vivo correlations,validation
Summary: 620-626 Achieving Antral Grinding Forces in Biorelevant In Vitro Models: Comparing the USP Dissolution Apparatus II and the Dynamic Gastric Model with Human In Vivo Data biorelevant in vitro models
AAPS PharmSciTech; Vol. 12 Number 2, Jun 2011;Published Date:05/31/2011; DOI: 10.1208/s12249-011-9616-z
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Author: Arthur Okumu, Marie DiMaso, Raimar Löbenberg
Keywords: ACAT,BCS,dynamic dissolution,IVIVC
Summary: The objectives of the study was to develop a dissolution test method that can be used to predict
flow-through cell dissolution method following a
Biorelevant dissolution media (BDM) prepared using bile salts and lecithin in
Pharmaceutical Research; Vol. 25 Number 12, Dec 2008;Published Date:11/30/2008; DOI: 10.1007/s11095-008-9642-z
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