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Author: Bei Li, Richard L. Schowen, Elizabeth M. Topp, Ronald T. Borchardt
Keywords: Peptides,deamidation,PVP,solid-state stability,N-1 position,N-2 position
Summary: The deamidation kinetics of 7 model peptides (VYPNGA, 7-9 Deamidation of a protein the rate of deamidation signifi cantly in the solid state but
The AAPS Journal; Vol. 8 Number 1, Mar 2006;Published Date:02/28/2006; DOI: 10.1208/aapsj080120
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Author: Andrew A. Kosky, Vasumathi Dharmavaram, Gayathri Ratnaswamy, Mark Cornell Manning
Keywords: asparagine deamidation rates,chemometrics,multivariate analysis,physicochemical property scales,projection to latent structures
Summary: To develop a quantitative scheme to describe and predict asparagine deamidation in
Deamidation rates for 306 pentapeptides, Gly-(n-1)-Asn-(n+1)-Gly, with the residues n-1 and
properties and the deamidation half-lives of the amino acid
Pharmaceutical Research; Vol. 26 Number 11, Nov 2009;Published Date:10/31/2009; DOI: 10.1007/s11095-009-9953-8
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Author: David F. Nellis, Dennis F. Michiel, Man-Shiow Jiang, Dominic Esposito, Richard Davis, Hengguang Jiang, Angela Korrell, George C. Knapp, Lauren E. Lucernoni, Roy E. Nelson, Emily M. Pritt, Lauren V. Procter, Mark Rogers, Terry L. Sumpter, Vinay V. Vyas, Timothy J. Waybright, Xiaoyi Yang, Amy M. Zheng, Jason L. Yovandich, John A. Gilly, George Mitra, Jianwei Zhu
Keywords: competing equilibria,deamidation,interleukin-15,kinetics,protein engineering
Summary: rhIL-15 deamidation was confirmed using RP-HPLC/ESI-MS, enzymatic labeling, and peptide mapping. Deamidation-resistant rhIL-15 variants (N77A, N77S, N77Q, G78A, and [N71S/N72A/N77A]) were produced deamidation
Pharmaceutical Research; Vol. 29 Number 3, Mar 2012;Published Date:02/29/2012; DOI: 10.1007/s11095-011-0597-0
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Author: Kasper Huus, Svend Havelund, Helle B. Olsen, Marco Weert, Sven Frokjaer
Keywords: chemical stability,deamidation,differential scanning calorimetry,dimerization,insulin,protein stability,thermal stability
Summary: the deamidation and covalent dimer formation rate when the insulin hexamer was not further stabilize Thermal stability can be used to predict the rate of AsnB3 deamidation in human insulin. chemical stability; deamidation; differential scanning calorimetry; dimerization; insulin;
Pharmaceutical Research; Vol. 23 Number 11, Nov 2006;Published Date:10/31/2006; DOI: 10.1007/s11095-006-9098-y
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Author: Melissa Perkins, Rolf Theiler, Susan Lunte, Margit Jeschke
Keywords: microheterogeneity,monoclonal antibody,deamidation,isoaspartate
Summary: tion, proteolytic fragmentation, and deamidation (6�9) partate in each of the isoforms indicated deamidation of MMA383 as
chains suggested the presence of one deamidation site on each of the
Pharmaceutical Research; Vol. 17 Number 9, Sep 2000;Published Date:08/31/2000; DOI: 10.1023/A:1026461830617
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Author: Wei Zhang, Marta J. Czupryn, Philip T. Boyle, John Amari
Keywords: interleukin-11,isomerization,deamidation,isoaspartate
Summary: can be produced by Asn deamidation and Asp isomerization
deamidation and aspartate (Asp) isomerization and to measure the
Asn deamidation and Asp isomerization in rhIL-11 with a
Pharmaceutical Research; Vol. 19 Number 8, Aug 2002;Published Date:07/31/2002; DOI: 10.1023/A:1019814713428
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Author: Sheng Yin, Cinthia V. Pastuskovas, Leslie A. Khawli, John T. Stults
Keywords: critical quality attributes,deamidation,in vivo circulated monoclonal antibody modifications,pyroglutamic acid,thioether/lanthionine
Summary: slower rates of deamidation, pyroE, and HC-S-LC formation. deamidation asparagine (Asn) deamidation, aspartic acid (Asp) isomerization, methionine (Met) and tryptophan (T
Pharmaceutical Research; Vol. 30 Number 1, Jan 2013;Published Date:12/31/2012; DOI: 10.1007/s11095-012-0860-z
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Author: Somnath Singh, Jagdish Singh
Keywords: differential scanning calorimeter,protein conformational stability,polyols,enzyme activity assay,lysozyme
Summary: aggregation, deamidation, and oxidation. sucrose against deamidation both at neutral pH and at Deamidation appears to be the most common degrada-
AAPS PharmSciTech; Vol. 4 Number 3, Sep 2003;Published Date:08/31/2003; DOI: 10.1208/pt040342
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