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Author: Linda Tollefson, William T. Flynn
Keywords: Antimicrobial resistance,animal drugs,foodborne disease,veterinary medicine
Summary: 1 Center for Veterinary Medicine, Food and Drug Administration, Rockville, MD 20855
associated with drug use in food-producing animals. Antimicrobial resistance, animal drugs,
The AAPS Journal; Vol. 4 Number 4, Dec 2002;Published Date:11/30/2002; DOI: 10.1208/ps040437
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Author: Qingcheng Mao
Keywords: BCRP,ATP-binding cassette,ABCG2,transporter,drug transport
Summary: role in clinical drug resistance of cancers. evidence that BCRP is a cause of drug resistance for certain
ing transporting drugs (xenobiotics) or drug conjugates and
The AAPS Journal; Vol. 7 Number 1, Mar 2005;Published Date:02/28/2005; DOI: 10.1208/aapsj070112
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Author: Quan Tian, Jing Zhang, Theresa May Chin Tan, Eli Chan, Wei Duan, Sui Yung Chan, Urs Alex Boelsterli, Paul Chi-Lui Ho, Hongyuan Yang, Jin-Song Bian, Min Huang, Yi-Zhun Zhu, Weiping Xiong, Xiaotian Li, Shufeng Zhou
Keywords: camptothecin,cyclophosphamide,drug transporter,multidrug resistance
Summary: The resistance profiles of test drugs in exponentially growing V/HepG2 and MRP4/ Based on the resistance folds from the MTT assay with 48 h exposure time of the test drug, camptothecin; cyclophosphamide; drug transporter; multidrug resistance.
Pharmaceutical Research; Vol. 22 Number 11, Nov 2005;Published Date:10/31/2005; DOI: 10.1007/s11095-005-7595-z
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Author: Ziping Yang, Micha Horn, Joanne Wang, Danny D Shen, Rodney JY Ho
Keywords: rat,MRP1,drug resistance,chemotherapeutic agents,cytotoxicity,transport,ATP-binding cassette,transwell
Summary: ABC-C, involved in conferring drug resistance to cancer riene C4 (LTC4), unmodified drugs, and some drugs induced drug resistance profile, compared with that of
The AAPS Journal; Vol. 6 Number 1, Mar 2004;Published Date:02/29/2004; DOI: 10.1208/ps060108
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Author: Jing Zhang, Ka-Yun Ng, Paul C. Ho
Keywords: cyclophosphamide,cytotoxicity,drug transporter,ifosfamide,multidrug resistance-associated protein 4
Summary: cells was found to confer significant resistance to CP and IF in the 48-h drug-exposure assays. several structurally and functionally unrelated drugs that do not
resistance include defective drug transport (reduced drug uptake
The AAPS Journal; Vol. 12 Number 3, Sep 2010;Published Date:08/31/2010; DOI: 10.1208/s12248-010-9189-x
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Author: Corbin J. Bachmeier, Donald W. Miller
Keywords: BCECF,blood-brain barrier,MRP,P-gp
Summary: multidrug resistance-associated protein (MRP) probe, BCECF (1 M), in bovine brain microvessel
and BCECF in assessing the drug efflux interactions of a variety of drugs in the BBB. decreased drug accumulation and drug response (5)
Pharmaceutical Research; Vol. 22 Number 1, Jan 2005;Published Date:12/31/2004; DOI: 10.1007/s11095-004-9016-0
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Author: Li Xing, Yiding Hu, Yurong Lai
Keywords: ABC transporters,ADME/Tox,MRP2/ABCC2,structure–activity relationship
Summary: Multidrug resistance-associated protein 2 (MRP2/ABCC2) is mainly expressed in the apical
porters could cause drug�drug interactions and related
role in pharmacokinetic properties, drug�drug interactions, and/
The AAPS Journal; Vol. 11 Number 3, Sep 2009;Published Date:08/31/2009; DOI: 10.1208/s12248-009-9117-0
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Author: Shanghua Yin, Changqing Zeng, Malathi Hari, Fernando Cabral
Keywords: cell division,drug resistance,microtubule assembly,mutant tubulin,neuronal disorders
Summary: a wider array of drug resistance mutations and demonstrated that similar mutations can cause paclit drug resistance and did not show resistance to drugs that do not interact with tubulin.
Pharmaceutical Research; Vol. 29 Number 11, Nov 2012;Published Date:10/31/2012; DOI: 10.1007/s11095-012-0794-5
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