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Author: Er-jia Wang, Christopher N. Casciano, Robert P. Clement, William W. Johnson
Keywords: sister-P-glycoprotein,BSEP,ABC-B11,drug interaction,inhibition,cholestasis
Summary: port of the fluorescent substrates dihydrofluorescein and bodipy. revealing incongruent relative sensitivities among the substrate mark- tial fluorescent substrates must be available to the cytoplas-
Pharmaceutical Research; Vol. 20 Number 4, Apr 2003;Published Date:03/31/2003; DOI: 10.1023/A:1023278211849
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Author: Bryan D. Marks, Tony A. Goossens, Heidi A. Braun, Mary S. Ozers, Ronald W. Smith, Connie Lebakken, Olga V. Trubetskoy
Keywords: Cytochrome P450,CYP2B6,fluorescent substrate,drug metabolism,high-throughput screening (HTS)
Summary: of endogenous substrates, such as steroids, fatty acids, and coumarin,9 have been used as fluorescent substrates for CYP2B6 Cyan Substrate, corresponding fluorescent dye
The AAPS Journal; Vol. 5 Number 2, Jun 2003;Published Date:05/31/2003; DOI: 10.1208/ps050218
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Author: Christopher P. Landowski, Hyo-kyung Han, Kyung-Dall Lee, Gordon L. Amidon
Keywords: fluorescent substrate,oligopeptide transporter,hPept1,HeLa,Caco-2,permeability
Summary: To synthesize fluorescent analogues of hPept1 substrates, eral studies with fluorescent peptide transporter substrates
fluorescent substrate; oligopeptide transporter;
Pharmaceutical Research; Vol. 20 Number 11, Nov 2003;Published Date:10/31/2003; DOI: 10.1023/B:PHAM.0000003369.64891.51
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Author: Olga Trubetskoy, Bryan Marks, Thomas Zielinski, Mei-Fei Yueh, Judy Raucy
Keywords: CYP3A4,induction,inhibition,DPX-2 cell line,drug-drug interactions
Summary: ined in reactions using Vivid fluorogenic substrates. substrates have been previously applied in P450 metabolism
of CYP3A4 substrates and inducers and enabling in-depth
The AAPS Journal; Vol. 7 Number 1, Mar 2005;Published Date:02/28/2005; DOI: 10.1208/aapsj070102
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Author: Shahrzad Missaghi, Reza Fassihi
Keywords: Film coating,film formation,confocal laser scanning microscopy (CLSM),adhesion test,magnet probe test
Summary: as a fluorescent marker, and were compressed using a the application of thin polymer-based layers to a substrate tion between the film and the substrates as well as the stabil-
AAPS PharmSciTech; Vol. 5 Number 2, Jun 2004;Published Date:05/31/2004; DOI: 10.1208/pt050229
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Author: Björn Bauer, David S. Miller, Gert Fricker
Keywords: blood—brain barrier,calcein-AM,compound profiling,microplate screening system,p-glycoprotein
Summary: However, the fluorescent marker sub- calcein-AM in the absence and presence of substrates and inhibitors
AM, a p-gp substrate (11)
Pharmaceutical Research; Vol. 20 Number 8, Aug 2003;Published Date:07/31/2003; DOI: 10.1023/A:1025040712857
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Author: Carlos Luna-Tortós, Bernhard Rambeck, Uwe H. Jürgens, Wolfgang Löscher
Keywords: blood-brain barrier,epilepsy,multidrug transporters,pharmacoresistance
Summary: In this respect, it is important to know which AEDs are substrates for such drug
drug transporters (Pgp, MRP1, MRP2 or MRP5) to evaluate whether the AED topiramate is a substrate
Known Pgp and MRP substrates were used for comparison.
Pharmaceutical Research; Vol. 26 Number 11, Nov 2009;Published Date:10/31/2009; DOI: 10.1007/s11095-009-9961-8
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Author: David A. Groneberg, Frank Döring, Monika Nickolaus, Hannelore Daniel, Axel Fischer
Keywords: uptake assay,visualizing,peptide transport,oligopeptides,kidney
Summary: fluorescent dipeptide derivative D-Ala-Lys-AMCA and unlabelled
of 25 M of the fluorescent dipeptide derivative D-Ala-Lys- identified earlier as specific peptide transporter substrate
Pharmaceutical Research; Vol. 19 Number 8, Aug 2002;Published Date:07/31/2002; DOI: 10.1023/A:1019810512519
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