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Author: Keith A. Hoffmaster, Ryan Z. Turncliff, Edward L. LeCluyse, Richard B. Kim, Peter J. Meier, Kim L. R. Brouwer
Keywords: cell culture,biliary excretion,drug transport,drug transport models,hepatocytes,P-glycoprotein
Summary: Primary hepatocytes have been used extensively for investi- the liver, primary hepatocytes lose both polarization and the
primary hepatocytes in a gelled collagen sandwich configura-
Pharmaceutical Research; Vol. 21 Number 7, Jul 2004;Published Date:06/30/2004; DOI: 10.1023/B:PHAM.0000033018.97745.0d
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Author: David Hallifax, Joanne A. Foster, J. Brian Houston
Keywords: clearance,hepatocytes,human,microsomes,prediction
Summary: from human hepatocytes and liver microsomes was compiled, microsomes and hepatocytes, respectively. only for hepatocytes, suggesting fundamental in vitro artefacts
Pharmaceutical Research; Vol. 27 Number 10, Oct 2010;Published Date:09/30/2010; DOI: 10.1007/s11095-010-0218-3
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Author: Valérie Haberkorn, Lucie Oziol, Hervé Goudonnet
Keywords: UDP-glucuronosyltransferase,9-cis-retinoic acid,thyroid hormone,hepatocytes,rats
Summary: rat primary hepatocytes. Hepatocytes from rats with various thyroid states were iso- The treatment of hepatocytes from hypo-
Pharmaceutical Research; Vol. 20 Number 10, Oct 2003;Published Date:09/30/2003; DOI: 10.1023/A:1026174931690
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Author: Brandon Swift, Wei Yue, Kim L. R. Brouwer
Keywords: 99mTechnetium-mebrofenin,99mTechnetium-sestamibi,sandwich-cultured hepatocytes,hepatic basolateral efflux,hepatic canalicular efflux
Summary: appears to passively diffuse into hepatocytes; biliary excretion is
sandwich-cultured hepatocytes (SCH) mined in suspended hepatocytes and in SCH in the presence
Pharmaceutical Research; Vol. 27 Number 9, Sep 2010;Published Date:08/31/2010; DOI: 10.1007/s11095-010-0203-x
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Author: Young-Sam Keum, Yong-Hae Han, Celine Liew, Jung-Hwan Kim, Changjiang Xu, Xiaoling Yuan, Michael P. Shakarjian, Saeho Chong, Ah-Ng Kong
Keywords: butylated hydroxyanisole (BHA),mitogen-activated protein kinases (MAPKs),Nrf2,tert-butylhydroquinone (tBHQ)
Summary: NQO1 and Nrf2 proteins and their regulatory mechanisms in primary-cultured hepatocytes. After exposure of BHA and tBHQ to primary-cultured rat and human hepatocytes and mouse
observed after BHA and tBHQ treatments in primary-cultured rat and human hepatocytes.
Pharmaceutical Research; Vol. 23 Number 11, Nov 2006;Published Date:10/31/2006; DOI: 10.1007/s11095-006-9094-2
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Author: Hélène Martin, Jean-Pierre Sarsat, Isabelle de Waziers, Chantal Housset, Pierre Balladur, Philippe Beaune, Véronique Albaladejo, Carole Lerche-Langrand
Keywords: CYP expression and induction,human liver slices,human hepatocytes,cyclophosphamide,phenobarbital
Summary: Cultured hepatocytes
to cultured human hepatocytes. human hepatocytes; cyclophosphamide; phenobarbital.
Pharmaceutical Research; Vol. 20 Number 4, Apr 2003;Published Date:03/31/2003; DOI: 10.1023/A:1023234429596
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Author: Masato Chiba, Yasuyuki Ishii, Yuichi Sugiyama
Keywords: hepatic clearance,human hepatocytes,human PK prediction,OATP1B1
Summary: hepatocytes, the systematic underpredictions of in vivo clearance have been commonly observed among
human hepatocytes as one of the versatile in vitro systems for
hepatocytes.
The AAPS Journal; Vol. 11 Number 2, Jun 2009;Published Date:05/31/2009; DOI: 10.1208/s12248-009-9103-6
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Author: Masanori Nakakariya, Taiki Shimada, Masanori Irokawa, Hiroyuki Koibuchi, Takashi Iwanaga, Hikaru Yabuuchi, Tomoji Maeda, Ikumi Tamai
Keywords: biliary excretion,hepatic uptake,oatp,organic anion,transporter
Summary: Nafcillin uptake by isolated rat hepatocytes was saturable with the Km of 210 mM and was
using freshly isolated rat hepatocytes and a tissue sampling
brane of hepatocytes, including organic anion transporting
Pharmaceutical Research; Vol. 25 Number 3, Mar 2008;Published Date:02/29/2008; DOI: 10.1007/s11095-007-9427-9
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