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Author: Subramaniam Ananthan, Wei Zhang, Judith Varady Hobrath
Keywords: GPCRs,homology modeling,virtual screening
Summary: for virtual screening of compound databases to identify new ligands for various GPCRs. Recent examples of such virtual screening against GPCRs are discussed in this review. overlay of the top-scoring compounds from this screen was
The AAPS Journal; Vol. 11 Number 1, Mar 2009;Published Date:02/28/2009; DOI: 10.1208/s12248-009-9094-3
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Author: Peter J Bugelski, Uzma Atif, Sarah Molton, Ilana Toeg, Peter G Lord, D. Gwyn Morgan
Keywords: cultured cells,data mining,correlation,National Cancer Institute Developmental Therapeutics Program
Summary: there is the potential to conduct a simple in vitro screen for
throughput screens for pharmacologic activity have created an in- egy for high throughput cytotoxicity screening:
Pharmaceutical Research; Vol. 17 Number 10, Oct 2000;Published Date:09/30/2000; DOI: 10.1023/A:1026495503939
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Author: Takashi Kojima, Satomi Onoue, Noriaki Murase, Fumie Katoh, Takashi Mano, Yoshihisa Matsuda
Keywords: crystalline form,polymorphism,Raman microscope,salt screening,tamoxifen
Summary: obtained from salt screening by using a
Tamoxifen salt screening was conducted with monobasic and polybasic acids on 96-well quartz
of the salt screening, tamoxifen citrate and fumarate salts were prepared on a large scale.
Pharmaceutical Research; Vol. 23 Number 4, Apr 2006;Published Date:03/31/2006; DOI: 10.1007/s11095-006-9644-7
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Author: Hong Mei, Walter Korfmacher, Richard Morrison
Keywords: oral exposure,pharmacokinetics,rat,screen
Summary: sure screening were evaluated by pharmacokinetic simula- rapid rat screen PK in rats can be important for proof-of-concept in rat dis- for high-throughput in vivo screening.
The AAPS Journal; Vol. 8 Number 3, Sep 2006;Published Date:08/31/2006; DOI: 10.1208/aapsj080358
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Author: David H. Johnson, Arun Parupudi, W. William Wilson, Lawrence J. DeLucas
Keywords: artificial neural network,formulation development,physical protein stability,self-interaction chromatography,systematic screening
Summary: incomplete factorial distribution of 81 formulation conditions of the screen components. parameters screened (12,636 conditions) interaction chromatography; systematic screening.
Pharmaceutical Research; Vol. 26 Number 2, Feb 2009;Published Date:01/31/2009; DOI: 10.1007/s11095-008-9737-6
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Author: Giulio Rastelli
Keywords: ADMET,drug discovery,molecular dynamics,structure-based virtual screening,virtual screening
Summary: virtual screening. virtual screening ABBREVIATIONS ADMET adsorption, distribution, metabolism, excretion, toxicity MM-G in both the screen-to-hit and the subsequent hit-to-lead processes.
Pharmaceutical Research; Vol. 30 Number 5, May 2013;Published Date:04/30/2013; DOI: 10.1007/s11095-013-1012-9
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Author: Steven A. Jacobs, Sheng-Jiun Wu, Yiqing Feng, Deidra Bethea, Karyn T. O’Neil
Keywords: aggregation,cross-interaction chromatography,monoclonal antibody,protein solubility
Summary: The technique was successfully used to screen microgram quantities of a panel of
methods can be rapidly screened for activity, specificity and
contrast to the high-throughput screening methods available
Pharmaceutical Research; Vol. 27 Number 1, Jan 2010;Published Date:12/31/2009; DOI: 10.1007/s11095-009-0007-z
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Author: Yeong Woo Jo, Byung Ho Woo, Azar M. Hazrati, Patrick P. DeLuca
Keywords: PharmASep,Microspheres,Microparticulate,Purge-air drying
Summary: inches, and a phase angle of 34.7o on the product screen. A 2-inch top screen with a 150-�m pore-opening screen cloth and a 6-inch product screen with a 25-�m pore-
AAPS PharmSciTech; Vol. 2 Number 1, Mar 2001;Published Date:02/28/2001; DOI: 10.1208/pt0201_tn2
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