|
Author: Alan Parr, Manish Gupta, Timothy H Montague, Frank Hoke
Keywords: bioequivalence,biopharmaceutics,quality by design,relative bioavailability,stable isotope
Summary: approach in using stable isotopes to reduce the number of subjects needed to perform relative bioav viability of the stable isotope approach. the application of stable isotopes to PK studies took the position of incorporating the stable isot
The AAPS Journal; Vol. 14 Number 3, Sep 2012;Published Date:08/31/2012; DOI: 10.1208/s12248-012-9371-4
|
|
Author: Junichi Kamiie, Sumio Ohtsuki, Ryo Iwase, Ken Ohmine, Yuki Katsukura, Kazunari Yanai, Yumi Sekine, Yasuo Uchida, Shingo Ito, Tetsuya Terasaki
Keywords: ABC transporter,LC/MS/MS,multiple reaction monitoring (MRM),pharmacoproteomics,SLC transporter
Summary: Mouse tissues were digested with trypsin, and mixed with stable isotope labeled-peptide as a
by using a triple-quadrupole mass spectrometer with stable
isotope-labeled peptides as internal references (11,16�20)
Pharmaceutical Research; Vol. 25 Number 6, Jun 2008;Published Date:05/31/2008; DOI: 10.1007/s11095-008-9532-4
|
|
Author: Damon I Papac, Zahra Shahrokh
Keywords: mass spectrometry,drug development,high throughput screening,pharmacokinetics,metabolite identification,mass balance,biomolecule characterization
Summary: spectrometry, chemical reaction interface-mass spectrometry and continuous flow-isotope ratio mass
and stable to heat, which significantly limited the range of
Pharmaceutical Research; Vol. 18 Number 2, Feb 2001;Published Date:01/31/2001; DOI: 10.1023/A:1011049231231
|
|
Author: Marina J. M. Maurer, Reinout C. A. Schellekens, Klaus D. Wutzke, Gerard Dijkstra, Herman J. Woerdenbag, Henderik W. Frijlink, Jos G. W. Kosterink, Frans Stellaard
Keywords: colon-delivery,local bioavailability,release profile,stable isotope,urea
Summary: We introduce an isotope dual-label approach (13C- and 15N2-urea) for colon drug delivery systems tha stable isotope
Pharmaceutical Research; Vol. 29 Number 8, Aug 2012;Published Date:07/31/2012; DOI: 10.1007/s11095-012-0735-3
|
|
Author: Parimal Samir, Andrew J. Link
Keywords: bioactive peptides,cryptides,cryptome,cryptomics,mass spectrometry-based proteomics
Summary: The AAPS Journal, Vol. 13, No. 2, June 2011 (# 2011)
DOI: 10.1208/s12248-011-9252-2
Mini-Review
Theme: Fishing for the Hidden Proteome in Health and Disease: Focus on Drug Abuse
Guest Editors: Rao
The AAPS Journal; Vol. 13 Number 2, Jun 2011;Published Date:05/31/2011; DOI: 10.1208/s12248-011-9252-2
|
|
Author: Surendra Bansal, Anthony DeStefano
Keywords: bioanalytical,validation,precision,accuracy,sensitivity,selectivity,reproducibility
Summary: The AAPS Journal 2007; 9 (1) Article 11 (http://www.aapsj.org).
Themed Issue: Bioanalytical Method Validation and Implementation: Best Practices for Chromatographic and Ligand Binding Assays
Guest
The AAPS Journal; Vol. 9 Number 1, Mar 2007;Published Date:02/28/2007; DOI: 10.1208/aapsj0901011
|
|
Author: Henri Benech, Alain Pruvost, Alain Batel, Michel Bourguignon, Jean-Louis Thomas, Jean-Marc Grognet
Keywords: magnesium,absolute bioavailability,stable isotopes,pharmacokinetics,ICP-MS
Pharmaceutical Research; Vol. 15 Number 2, Feb 1998;Published Date:01/31/1998; DOI: 10.1023/A:1011947525377
|
|
Author: Jin-Zhu Wu, Paul C. Ho
Keywords: arsenite,orpiment,oxidative DNA damage,realgar,8-hydroxy-2′-deoxyguanosine
Summary: 8-OH-dGuo in urine was quantified with isotope-dilution liquid chromatography coupled with
Stable heavy isotope labeled [15N5]-8-OH- dGuo (98% in purity) was obtained from Cambridge Isotope
Pharmaceutical Research; Vol. 26 Number 6, Jun 2009;Published Date:05/31/2009; DOI: 10.1007/s11095-009-9865-7
|